ICMDA's East Africa region covers the newly formed South Sudan and the horn of Africa down to Tanzania in the South. There are 10 countries or territories here with a combined population of 317 million people, of whom over a third live in Ethiopia.

There are six affiliated groups in the region with the oldest being Uganda's CMF and the newest in Rwanda, who joined in 2023.

There is a strong Christian presence in East Africa, with many of the countries being more than 20% evangelical.

There are 84 medical schools in the region and on average just seven healthcare workers to serve every 10,000 people.