ICMDA's East Africa region covers the mainland area from DRC eastward to the horn of Africa, including Madagascar and the smaller islands surrounding it. There are 17 countries/territories here with a combined population of 445 million people.

There are eight affiliated groups in the region with the oldest being Uganda's CMF. Three new groups from Burundi, DRC and Madagascar joined ICMDA at the 2018 World Congress in Hyderabad.

There is a strong Christian presence in East Africa, with five countries being more than 25% evangelical.

There are 87 medical schools in the region and on average just seven healthcare workers to serve every 10,000 people.